Senior Principal Scientist I - Functional Biomarkers
Company: Sanofi
Location: Cambridge
Posted on: March 31, 2026
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Job Description:
Job Title: Senior Principal Scientist I - Functional Biomarkers
Location: Cambridge, MA About the Job Functional group leader in
the US Laboratory Sciences group, a global department within the
Translational Medicine Unit of Sanofi. The individual in this
position will lead a group of scientists and analysts to develop,
validate and implement complex immunophenotyping panels and
functional biomarker assays in a regulated environment. The
successful candidate should have an extensive background in flow
cytometry instrumentation and troubleshooting, high-parameter panel
development, and cell sorting along with expertise in assay design,
method validation, and analytical interpretation of results along
with proven people management skills. Join the engine of Sanofis
mission where deep immunoscience meets bold, AI-powered research.
In R&D, youll drive breakthroughs that could turn the
impossible into possible for millions. About Sanofi: Were an
R&D-driven, AI-powered biopharma company committed to improving
peoples lives and delivering compelling growth. Our deep
understanding of the immune system and innovative pipeline enables
us to invent medicines and vaccines that treat and protect millions
of people around the world. Together, we chase the miracles of
science to improve peoples lives. Main Responsibilities: Lead and
manage local teams to develop, validate, and implement complex cell
staining panels upwards of 30 colors according to, or exceeding the
highest scientific and applicable regulatory (GLP, GCLP) standards.
Oversee method development and/or transfer and implementation of
complex immunophenotyping panels at dedicated CROs. Serve as a flow
cytometry subject matter expert; provide scientific oversight and
data interpretation and ensure data generated internally or with
CROs meets compliance requirements according to internal best
practices and regulatory guidance. Serve as bioanalytical lead on
global project teams: Work with global teams to develop and
operationalize testing strategies to support new and ongoing
clinical programs. Ensure that all methods are in place to meet
critical deliverables. Lead team to prepare high quality standard
operating procedures, study plans and reports. Lead global Sanofi
efforts to develop best practices and guidance documents for
regulated bioanalysis. Contribute to implementation of best
practices industry-wide through participation in external
scientific organizations Take a leadership role in ensuring
regulatory and safety compliance in the laboratory; promote
operational excellence by leading process improvement efforts.
Prioritize multiple project commitments under the confines of
challenging timelines. Plan proactively, anticipating challenges
and future goals. Make decisions readily understanding the impact
on Sanofi success and demonstrate agility relating to change. Lead
efforts to implement AI tools to streamline method development and
data analysis workflows. About you Basic Qualifications Ph.D.
degree in the field of immunology, biochemistry, biology, or other
life-science field with 7 years of post-graduate industry
experience, or Masters degree in a similar field with 10 years of
industry experience. Expertise with flow cytometer instruments and
their associated software including AI tools. A diverse skillset in
bioanalytical assay techniques such as cell culture, cell imaging,
ligand binding, receptor occupancy or enzyme activity assays.
Outstanding written and oral communication skills along with the
ability to work collaboratively in a team setting. Demonstrated
knowledge and skills in solving scientific problems, ability to
troubleshoot. Proven ability to lead teams and direct the work of
staff members at all levels. Other Qualifications: Experience in
immunology. Demonstrated experience in complex immunophenotyping
assay development and implementation in clinical trials in line
with industrys best practices and current regulatory expectations
for validation of flow cytometry assays. Experience working with a
laboratory information system, such as Watson LIMS, to manage
sample tracking and data analysis. Experience using an electronic
laboratory notebook. Knowledge of biological sample collection
techniques and their suitability for different types of analysis.
Experience validating software and equipment in a regulated
laboratory setting. Experience in implementation of a variety of
methods, such as ligand binding or mass spectrometry, in a
regulated setting. Experience working withQuality Assurance in a
compliance-related environment. Knowledge of requirements for
working in a regulated environment (GLP, GCLP, CLIA) in support of
nonclinical and/or clinical development projects. Exposure to
working withQuality teams in a GxP environment. Experience
supporting regulatory filings. Experience with clinical trial
operations. Why Choose Us Bring the miracles of science to life
alongside a supportive, future-focused team. Discover endless
opportunities to grow your talent and drive your career, whether
its through a promotion or lateral move, at home or
internationally. Enjoy a thoughtful, well-crafted rewards package
that recognizes your contribution and amplifies your impact. Take
good care of yourself and your family, with a wide range of health
and wellbeing benefits including high-quality healthcare,
prevention and wellness programs and at least 14 weeks
gender-neutral parental leave. Be part of a pioneering biopharma
company that engages patients early in drug development and uses
their insights to design studies that reflect real-world needs.
Help improve the lives of millions of people globally by making
drug development quicker and more effective. Work at the forefront
of drug discovery, harnessing cutting-edge AI, data, and digital
platforms to push the boundaries of science. Sanofi Inc. and its
U.S. affiliates are Equal Opportunity and Affirmative Action
employers committed to a culturally diverse workforce. All
qualified applicants will receive consideration for employment
without regard to race; color; creed; religion; national origin;
age; ancestry; nationality; marital, domestic partnership or civil
union status; sex, gender, gender identity or expression;
affectional or sexual orientation; disability; veteran or military
status or liability for military status; domestic violence victim
status; atypical cellular or blood trait; genetic information
(including the refusal to submit to genetic testing) or any other
characteristic protected by law. GD-SG LI-GZ LI-Onsite vhd All
compensation will be determined commensurate with demonstrated
experience. Employees may be eligible to participate in Company
employee benefit programs, and additional benefits information can
be found here.
Keywords: Sanofi, Cranston , Senior Principal Scientist I - Functional Biomarkers, Science, Research & Development , Cambridge, Rhode Island
